Platelet rich fibrin: New treatment modality in Grade II furcation defects

Plateletrich rich fibrin (PRF) is an autologous healing biomaterial, which incorporates a matrix of autologous fibrin, leukocytes, platelets and growth factors, harvested from a simple blood sample. Various growth factors present in PRF are well-known source of cytokines, usable for clinical applications. Grade II furcation lesion is essentially a cul-de-sac with a definite horizontal component and involvement of the interradicular bone without a through-and-through ability to probe. Furcation defects represent a formidable problem in the treatment of periodontal disease, which is related to the complex and irregular anatomy of furcation. The early Grade II furcation requires surgical management. Surgery permits access for root debridement, odontoplasty, osseous recontouring, and periodontal regeneration. Regeneration of the previously destroyed periodontal attachment tissues is biologically possible, and the regeneration has become the goal of therapy since the 1990s. Regenerative attempts such as bone grafts, guided tissue regeneration, application of growth factors, and enamel matrix derivatives are currently used for periodontal regeneration in the treatment of Grade II furcation involvements which under favorable conditions, can induce roughly 60-70% regeneration of the bone lesion’s height or volume, with concomitant improvement in the clinical conditions. This review will help in understanding regenerative property of PRF in furcation defects.